Pure Encapsulations P5P50 (activated B-6)

P5P50 (activated B-6)
P5P50 (activated B-6)
Item# p5p50
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Pure Encapsulations P5P50 (activated B-6)

What Is It?

P5P50 is pyridoxal 5' phosphate (P5P), the active metabolite and predominant form of plasma pyridoxine (vitamin B6).*

Uses For P5P50

Menstrual Comfort: Clinical trials have indicated that vitamin B6 may support menstrual comfort, in part by maintaining healthy neurotransmitter function to promote healthy mood and mental functioning.*

Nervous System Support: Vitamin B6 plays an integral role in the synthesis of neurotransmitters and helps maintain the cellular balance of sodium and potassium. These roles serve to promote the healthy functioning of the nervous system. This vitamin may also provide specific support for wrist nerve comfort as reported in some but not all studies.*

Various Physiological Support Properties: P5P50 is beneficial to a number of physiological functions, providing a wide range of nutritional support. P5P is required for proper absorption of B12 and magnesium, and for the production of gastric HCl. It is an important coenzyme in the metabolism of carbohydrates, fats, and proteins, and the elongation of essential fatty acids. It is also required for the production of antibodies and red blood cells.*

What Is The Source?

Pure Encapsulations P5P50 is synthetically derived. Vitamin C (ascorbyl palmitate) is derived from corn dextrose fermentation and palm oil. Hypo-allergenic plant fiber is derived from pine cellulose.

Are There Any Potential Side Effects Or Precautions?

If pregnant or lactating, consult your physician before taking this product. Individuals experiencing numbness or tingling with vitamin B6 supplementation should notify their health professional, as vitamin B6 may adversely affect sensory nerves in some individuals (though this effect is more likely to occur at doses greater than 200 mg). Consult your physician for more information.


1. Ellis J, Folkers K, Watanabe T, Kaji M, Saji S, Caldwell JW, Temple CA, Wood FS. Clinical results of a cross-over treatment with pyridoxine and placebo of the carpal tunnel syndrome. Am J Clin Nutr 1979 Oct;32(10):2040 6.

2. Doll H, Brown S, Thurston A, Vessey M. J R Pyridoxine (vitamin B6) and the premenstrual syndrome: a randomized crossover trial. Coll Gen Pract 1989 Sep;39(326):364-8.

3. Heap LC, Peters TJ, Wessely S. Vitamin B status in patients with chronic fatigue syndrome. J R Soc Med 1999 Apr;92(4):183-5.

4. Lerner V, Miodownik C, Kaptsan A, Cohen H, Matar M, Loewenthal U, Kotler M. Vitamin B(6) in the treatment of tardive dyskinesia: a double-blind, placebo-controlled, crossover study. Am J Psychiatry 2001 Sep;158(9):1511-4.

5. Healthnotes Clinical Essentials. Copyright 2003. Healthnotes, Inc.


Pure Encapsulations recommends 2 capsules per day, in divided doses, with meals.

Each VCapsule Contains:

pyridoxal 5' phosphate (activated B6) 50 mg.

vitamin C (as ascorbyl palmitate 3 mg.

(hypo-allergenic plant fiber added to complete capsule volume requirement)

Suggested Use:

2 vegetarian capsules per day, in divided doses, with meals.

*This is a statement of nutritional support. This statement has not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. For educational purposes only. Consult your physician for any health problems.