Pure Encapsulations P5P50 (activated B-6)
What Is It?
P5P50™ is pyridoxal 5' phosphate (P5P), the active
metabolite and predominant form of plasma pyridoxine
Uses For P5P50™
Menstrual Comfort: Clinical trials have indicated that
vitamin B6 may support menstrual comfort, in part by
maintaining healthy neurotransmitter function to promote
healthy mood and mental functioning.*
Nervous System Support: Vitamin B6 plays an integral
role in the synthesis of neurotransmitters and helps
maintain the cellular balance of sodium and potassium.
These roles serve to promote the healthy functioning of
the nervous system. This vitamin may also provide
specific support for wrist nerve comfort as reported in
some but not all studies.*
Various Physiological Support Properties: P5P50™ is
beneficial to a number of physiological functions,
providing a wide range of nutritional support. P5P is
required for proper absorption of B12 and magnesium, and
for the production of gastric HCl. It is an important
coenzyme in the metabolism of carbohydrates, fats, and
proteins, and the elongation of essential fatty acids. It is also required for the production of antibodies and red
What Is The Source?
Pure Encapsulations P5P50 is synthetically derived. Vitamin
C (ascorbyl palmitate) is derived from corn dextrose
fermentation and palm oil. Hypo-allergenic plant fiber is
derived from pine cellulose.
Are There Any Potential Side Effects Or Precautions?
If pregnant or lactating, consult your physician before
taking this product. Individuals experiencing numbness or
tingling with vitamin B6 supplementation should notify
their health professional, as vitamin B6 may adversely
affect sensory nerves in some individuals (though this
effect is more likely to occur at doses greater than
200 mg). Consult your physician for more information.
1. Ellis J, Folkers K, Watanabe T, Kaji M, Saji S, Caldwell JW, Temple CA,
Wood FS. Clinical results of a cross-over treatment with pyridoxine and
placebo of the carpal tunnel syndrome. Am J Clin Nutr 1979 Oct;32(10):2040 6.
2. Doll H, Brown S, Thurston A, Vessey M. J R Pyridoxine (vitamin B6) and
the premenstrual syndrome: a randomized crossover trial. Coll Gen Pract
3. Heap LC, Peters TJ, Wessely S. Vitamin B status in patients with chronic
fatigue syndrome. J R Soc Med 1999 Apr;92(4):183-5.
4. Lerner V, Miodownik C, Kaptsan A, Cohen H, Matar M, Loewenthal U,
Kotler M. Vitamin B(6) in the treatment of tardive dyskinesia: a double-blind,
placebo-controlled, crossover study. Am J Psychiatry 2001 Sep;158(9):1511-4.
5. Healthnotes Clinical Essentials. Copyright 2003. Healthnotes, Inc.
Pure Encapsulations recommends 2 capsules per day, in
divided doses, with meals.
Each VCapsule Contains:
pyridoxal 5' phosphate (activated B6) 50 mg.
vitamin C (as ascorbyl palmitate 3 mg.
(hypo-allergenic plant fiber added to complete capsule volume requirement)
2 vegetarian capsules per day, in divided doses, with meals.
*This is a statement of nutritional support. This statement has not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. For educational purposes only. Consult your physician for any health problems.